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Review
. 2007 Jan;26(1):4-6.
doi: 10.1016/j.immuni.2007.01.006.

IVIG therapy: interfering with interferon-gamma

Raphael Clynes  1
Affiliations
Free article
Review

IVIG therapy: interfering with interferon-gamma

Raphael Clynes. Immunity. 2007 Jan.
Free article

Abstract

The immunosuppressive mechanism of action of intravenous immune globulin (IVIG) has remained enigmatic despite the many years of clinical experience in the treatment of autoimmunity. In this issue of Immunity, Park-Min et al. demonstrate that IVIG engagement of Fcgamma RIII receptor on monocytes inhibits the cellular response to interferon-gamma.

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