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Review
. 2007 Jan 26;25(2):175-6.
doi: 10.1016/j.molcel.2007.01.008.

Life without kinase: cyclin E promotes DNA replication licensing and beyond

Hui Zhang  1
Affiliations
Free article
Review

Life without kinase: cyclin E promotes DNA replication licensing and beyond

Hui Zhang. Mol Cell. .
Free article

Abstract

In a recent issue of Molecular Cell, Sicinski and colleagues report the surprising discovery that cyclin E promotes replication licensing and transformation independently of CDKs, resolving inconsistencies of inactivating cyclin E and CDK2 in the mouse and cells.

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Comment on

  • Kinase-independent function of cyclin E.
    Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P. Geng Y, et al. Mol Cell. 2007 Jan 12;25(1):127-39. doi: 10.1016/j.molcel.2006.11.029. Mol Cell. 2007. PMID: 17218276

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