The scoop on Sco
- PMID: 17244525
- DOI: 10.1016/j.molcel.2007.01.007
The scoop on Sco
Abstract
In the January 3 issue of Cell Metabolism, report that the mitochondrial metallochaperones Sco1 and Sco2, essential for cytochrome c oxidase assembly, are also responsible for maintenance of cell copper homeostasis, thus showing a new function of mitochondria.
Similar articles
-
The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.Cell Metab. 2007 Jan;5(1):9-20. doi: 10.1016/j.cmet.2006.12.001. Cell Metab. 2007. PMID: 17189203
-
Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.Hum Mol Genet. 2004 Sep 1;13(17):1839-48. doi: 10.1093/hmg/ddh197. Epub 2004 Jun 30. Hum Mol Genet. 2004. PMID: 15229189
-
Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.Hum Mol Genet. 2009 Jun 15;18(12):2230-40. doi: 10.1093/hmg/ddp158. Epub 2009 Mar 31. Hum Mol Genet. 2009. PMID: 19336478
-
Redox regulation of SCO protein function: controlling copper at a mitochondrial crossroad.Antioxid Redox Signal. 2010 Nov 1;13(9):1403-16. doi: 10.1089/ars.2010.3116. Antioxid Redox Signal. 2010. PMID: 20136502 Review.
-
Biogenesis of cytochrome oxidase-sophisticated assembly lines in the mitochondrial inner membrane.Gene. 2005 Jul 18;354:43-52. doi: 10.1016/j.gene.2005.03.017. Gene. 2005. PMID: 15905047 Review.
Cited by
-
Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity.Genome Biol Evol. 2023 Aug 1;15(8):evad135. doi: 10.1093/gbe/evad135. Genome Biol Evol. 2023. PMID: 37481257 Free PMC article.
-
Cooperation between two periplasmic copper chaperones is required for full activity of the cbb3 -type cytochrome c oxidase and copper homeostasis in Rhodobacter capsulatus.Mol Microbiol. 2016 Apr;100(2):345-61. doi: 10.1111/mmi.13321. Epub 2016 Feb 28. Mol Microbiol. 2016. PMID: 26718481 Free PMC article.
-
Mitochondrial copper metabolism and delivery to cytochrome c oxidase.IUBMB Life. 2008 Jul;60(7):421-9. doi: 10.1002/iub.50. IUBMB Life. 2008. PMID: 18459161 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources