Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991;21(3):165-76.
doi: 10.1007/BF01809445.

Origin of genetically encoded protein synthesis: a model based on selection for RNA peptidation

J T Wong  1
Affiliations

Origin of genetically encoded protein synthesis: a model based on selection for RNA peptidation

J T Wong. Orig Life Evol Biosph. 1991.

Abstract

The difficulty in explaining the origin of genetic coding centres on the need to identify selective advantages that could account for the synthesis of peptidyl-tRNA, the essential intermediate in genetically programmed translation. It is resolved by a recognition of the functional advantages derivable from the post-transcriptional addition of peptide cofactors to RNA apo-catalysts. This enables the formulation of a theory for the origin of the genetic encoding of protein synthesis by RNA.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1271-5 - PubMed
    1. Annu Rev Biochem. 1986;55:599-629 - PubMed
    1. Annu Rev Biochem. 1988;57:69-99 - PubMed
    1. Arch Biochem Biophys. 1987 May 15;255(1):176-83 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2336-40 - PubMed

Publication types