Induction of Mutations by gamma-Rays in Pregonial Germ Cells of Zebrafish Embryos
- PMID: 17246099
- PMCID: PMC1202017
- DOI: 10.1093/genetics/103.1.125
Induction of Mutations by gamma-Rays in Pregonial Germ Cells of Zebrafish Embryos
Abstract
Specific locus (gol-1) germ line mutations are induced by gamma-rays with high frequencies (about 10(-5) r( -1)) during cleavage divisions in zebrafish. Mutant clone sizes range from 3 to 50% of the total number of germ cells, with a mean of about 10%, when embryos are exposed between the 16 and 10(3) cell stages. About five pregonial cells are calculated to be present during the cleavage period.
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