doi: 10.1002/ijc.2910160613.
Detection of virus-specific DNA and RNA base-sequences in individual cells transformed or infected by adenovirus type 2
- PMID: 172461
- DOI: 10.1002/ijc.2910160613
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Detection of virus-specific DNA and RNA base-sequences in individual cells transformed or infected by adenovirus type 2
Int J Cancer.
.
Abstract
By means of 3H thymidine-labelled adenovirus 2 DNA, adenovirus-specific DNA sequences have been localized in individual nuclei of adenovirus 2- or 12-infected cells, and adenovirus-specific RNA sequences have been detected in the permissive cells as well as in cells transformed by adenovirus type 2. The ability to detect such specific virus RNA base-sequences in particular, by in situ hybridization, should be useful in studying the transcriptional specificities of tumours and neoplasms.
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