Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Nov;104(3):714-8.
doi: 10.1111/j.1476-5381.1991.tb12493.x.

Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

B Allard  1 , V Jacquemond, F Lemtiri-Chlieh, B Pourrias, O Rougier
Affiliations

Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

B Allard et al. Br J Pharmacol. 1991 Nov.

Abstract

1. Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2. Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. 4. The action of heptaminol was suppressed in sodium-free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. 5. These results could be explained by a stimulation of the Na/H antiport by heptaminol.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. C R Seances Soc Biol Fil. 1964;158:1850-3 - PubMed
    1. C R Seances Soc Biol Fil. 1961;155:2404-6 - PubMed
    1. C R Seances Soc Biol Fil. 1958;152(6):923-5 - PubMed
    1. C R Seances Soc Biol Fil. 1953 May;147(9-10):774-9 - PubMed
    1. J Physiol. 1991 Feb;433:705-17 - PubMed

Publication types

LinkOut - more resources