Glutamate oxaloacetate transaminase (got) genetics in the mouse: polymorphism of got-1
- PMID: 17248564
- PMCID: PMC1212735
- DOI: 10.1093/genetics/70.2.299
Glutamate oxaloacetate transaminase (got) genetics in the mouse: polymorphism of got-1
Abstract
We have examined a polymorphism for the soluble glutamate oxaloacetate (GOT-1) isozyme system which was found in the Asian mouse Mus castaneus. Variants of GOT-1 segregate as though they are controlled by codominant alleles for a single autosomal locus which we have designated Got-1. No close linkage of genes for soluble and mitochondrial forms of the enzyme, GOT-1 and GOT-2 respectively, was observed. Furthermore, no close linkage of Got-1 and the loci c, Gpi-1, Mod-2, Mod-1, Ld-1, Gpd-1, Pgm-1 or Gpo-1 was observed. Our results demonstrate the utility of sampling Mus from diverse populations to extend the repertoire of polymorphic loci and the genetic linkage map.
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