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. 1979 Apr;91(4):627-37.
doi: 10.1093/genetics/91.4.627.

Frequency-Dependent Selection for Plasmid-Containing Cells of ESCHERICHIA COLI

J Adams, T Kinney, S Thompson, L Rubin, R B Helling

Frequency-Dependent Selection for Plasmid-Containing Cells of ESCHERICHIA COLI

J Adams et al. Genetics. 1979 Apr.

Abstract

Colicin-producing plasmid-containing cells of E. coli exhibit frequency-dependent selection when grown in glucose-limited continuous culture with the corresponding plasmid-free strain. The bases of this frequency-dependent effect are shown to be (1) the lower growth rate of the plasmid-containing strain under these conditions, and (2) the production of colicin, which attenuates the growth rate of the plasmid-free strain. These results are discussed in relationship to the maintenance of genetic variation in prokaryotes.

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