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. 1980 Apr;94(4):961-8.
doi: 10.1093/genetics/94.4.961.

Spontaneous Allozyme Mutations in DROSOPHILA MELANOGASTER: Rate of Occurrence and Nature of the Mutants

R A Voelker  1 , H E Schaffer, T Mukai
Affiliations

Spontaneous Allozyme Mutations in DROSOPHILA MELANOGASTER: Rate of Occurrence and Nature of the Mutants

R A Voelker et al. Genetics. 1980 Apr.

Abstract

After additional generations of accumulation of allozyme mutants, the 1,000 lines of Mukai and Cockerham (1977) were again screened for the same five loci (alpha-Gpdh, cMdh, Adh, Hex-C and alpha-Amy), as well as for two new loci (Got-2 and Dip-A). Based on 3,111,598 allele generations: (1) the average mutation rate to new mobility variants with normal function was estimated to be 1.28 x 10(-6), and (2) the average mutation rate to null alleles was estimated to be 3.86 x 10(-6). A qualitative analysis of the nulls provided evidence that most of the mutants recovered are due to base substitutions. No apparent correlation was observed between structural gene size and mutation rate.

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References

    1. Mutat Res. 1970 May;9(5):527-49 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2514-7 - PubMed

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