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. 2007 Feb 1;9(3):457-60.
doi: 10.1021/ol062808f.

Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions

Myra Beaudoin Bertrand  1 , Matthew L Leathen, John P Wolfe
Affiliations

Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions

Myra Beaudoin Bertrand et al. Org Lett. .

Abstract

[reaction: see text] The palladium-catalyzed carboamination of N-protected gamma-aminoalkenes with aryl bromides and triflates has been achieved under new, mild reaction conditions using the weak base Cs(2)CO(3) in dioxane solvent. These reactions tolerate a wide variety of functional groups, including enolizable ketones, nitro groups, methyl esters, and acetates, which are not compatible with previously described conditions.

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Figures

Scheme 1
Scheme 1
Stereoselective Synthesis of 25
See this image and copyright information in PMC

References

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    1. Dpe-phos = bis(2-diphenylphosphinophenyl)ether.

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