doi: 10.1248/bpb1978.14.393.
Relationship between substance P-induced initial transient contractions and inositol phospholipid hydrolysis in guinea pig ileum
Affiliations
- PMID: 1724988
- DOI: 10.1248/bpb1978.14.393
Item in Clipboard
Relationship between substance P-induced initial transient contractions and inositol phospholipid hydrolysis in guinea pig ileum
J Pharmacobiodyn.
1991 Jul.
Abstract
The effects of neomycin on substance P (SP)-induced inositol phospholipid hydrolysis and muscle contraction were studied in longitudinal smooth muscle of guinea pig ileum. Various tachykinin peptides including SP stimulated inositol phospholipid hydrolysis in guinea pig ileum. Neomycin (2.5 mM) reduced both the contractions and the accumulation of [3H]inositol phosphates induced by SP. These results suggest that the initial transient contractions induced by SP are coupled to inositol phospholipid hydrolysis.
Similar articles
-
Neurokinin3-receptors are linked to inositol phospholipid hydrolysis in the guinea-pig ileum longitudinal muscle-myenteric plexus preparation.Br J Pharmacol. 1988 May;94(1):148-54. doi: 10.1111/j.1476-5381.1988.tb11509.x. Br J Pharmacol. 1988. PMID: 2456806 Free PMC article.
-
Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus.Eur J Pharmacol. 1983 Sep 30;93(3-4):245-53. doi: 10.1016/0014-2999(83)90144-9. Eur J Pharmacol. 1983. PMID: 6196211
-
Histamine-induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea-pig ileum.Br J Pharmacol. 1985 Jun;85(2):499-512. doi: 10.1111/j.1476-5381.1985.tb08887.x. Br J Pharmacol. 1985. PMID: 2992666 Free PMC article.
-
Pharmacological characterization of tachykinin-stimulated inositol phospholipid hydrolysis in peripheral tissues.Br J Pharmacol. 1990 Dec;101(4):1001-5. doi: 10.1111/j.1476-5381.1990.tb14196.x. Br J Pharmacol. 1990. PMID: 1707702 Free PMC article.
-
Effect of the tachykinin antagonist, [D-Pro4, D-Trp7,9,10] substance P-(4-11), on tachykinin- and histamine-induced inositol phosphate generation in intestinal smooth muscle.Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):296-300. doi: 10.1007/BF00172800. Naunyn Schmiedebergs Arch Pharmacol. 1987. PMID: 2438561