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Comparative Study
. 2007 Feb;13(1):19-24.
doi: 10.1111/j.1600-0846.2006.00179.x.

Porcine ear skin: an in vitro model for human skin

Ute Jacobi  1 , Marco Kaiser, Rani Toll, Susanne Mangelsdorf, Heike Audring, Nina Otberg, Wolfram Sterry, Juergen Lademann
Affiliations
Comparative Study

Porcine ear skin: an in vitro model for human skin

Ute Jacobi et al. Skin Res Technol. 2007 Feb.

Abstract

Background/purpose: Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The structure of this tissue, including hair follicles, was studied qualitatively and quantitatively in comparison with human skin.

Methods: Sections of shock-frozen biopsies, biopsies embedded in paraffin and cyanoacrylate skin surface biopsies were investigated using microscopy. The thickness of the different skin layers and the follicular characteristics were determined.

Results: The thickness of the stratum corneum was 17-28 microm, whereas the viable epidermis was 60-85 microm thick. On 1 cm(2), 11-25 hairs were detected, showing a diameter of 58-97 microm and a maximal extension depth of 0.96-1.38 mm into the skin. The orifices of the porcine infundibula showed a diameter of approximately 200 microm.

Conclusions: The results obtained are similar to those of human skin, indicating the suitability of this porcine tissue as a model for human skin.

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