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Review
. 2007 Feb 1;120(Pt 3):385-93.
doi: 10.1242/jcs.03363.

Wnt signalling: variety at the core

Stefan Hoppler  1 , Claire Louise Kavanagh
Affiliations
Review

Wnt signalling: variety at the core

Stefan Hoppler et al. J Cell Sci. .

Abstract

The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.

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