A genetics perspective on prostate cancer

Abstract

Prostate cancer is the most common malignancy and the second leading cause of cancer-related deaths among American men. In a small percentage of men, prostate cancer occurs as a result of inheriting a mutation in a major gene predisposing to this disease. The genome-wide search for prostate cancer susceptibility genes holds the promise of making genetic testing for prostate cancer risk available in the future and for ultimately developing better tools for disease prevention, diagnosis, and treatment. Nursing practice roles are increasingly affected by the translation of rapidly expanding genetic knowledge into the patient care arena. The current advances in the genetic basis of prostate cancer, including screening and management aspects and risk assessment considerations for urologic nursing practice, are addressed.