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Controlled Clinical Trial
. 2007 Jun;87(6):1487-90.
doi: 10.1016/j.fertnstert.2006.11.021. Epub 2007 Jan 24.

Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome

Hiroaki Shibahara  1 , Kumiko Kikuchi, Yuki Hirano, Tatsuya Suzuki, Satoru Takamizawa, Mitsuaki Suzuki
Affiliations
Controlled Clinical Trial

Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome

Hiroaki Shibahara et al. Fertil Steril. 2007 Jun.

Abstract

Metformin appears to be an effective medicine to induce ovulation in women with polycystic ovary syndrome and insulin resistance. After the introduction of metformin treatment for such cases, the use of gonadotropin in combination with metformin significantly increased the incidence of multiple pregnancies.

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