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Review
. 2007 Jan 26;128(2):233-4.
doi: 10.1016/j.cell.2007.01.005.

Oncogene-induced senescence pathways weave an intricate tapestry

Paul Yaswen  1 , Judith Campisi
Affiliations
Free article
Review

Oncogene-induced senescence pathways weave an intricate tapestry

Paul Yaswen et al. Cell. .
Free article

Abstract

The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.

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