Review
doi: 10.1016/j.cell.2007.01.009.
FoxOs in tumor suppression and stem cell maintenance
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- PMID: 17254960
- DOI: 10.1016/j.cell.2007.01.009
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Review
FoxOs in tumor suppression and stem cell maintenance
Cell.
.
Free article
Abstract
The FoxO transcription factors have been implicated in many processes including tumor suppression and cell death. In this issue, two groups now report on mice that conditionally lack the three predominant FoxO transcription factors. Demonstrate that FoxOs are critical for the long-term maintenance of hematopoietic stem cells, and show that FoxOs suppress the formation of hemangiomas and lymphomas in mice.
Comment on
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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.Cell. 2007 Jan 26;128(2):309-23. doi: 10.1016/j.cell.2006.12.029. Cell. 2007. PMID: 17254969 Free PMC article.
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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.Cell. 2007 Jan 26;128(2):325-39. doi: 10.1016/j.cell.2007.01.003. Cell. 2007. PMID: 17254970
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