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Review
. 2007 Jan 26;128(2):239-40.
doi: 10.1016/j.cell.2007.01.010.

Phosphoinositides specify polarity during epithelial organ development

Frank I Comer  1 , Carole A Parent
Affiliations
Free article
Review

Phosphoinositides specify polarity during epithelial organ development

Frank I Comer et al. Cell. .
Free article

Abstract

The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity.

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