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Comment
. 2007 Feb;170(2):436-8.
doi: 10.2353/ajpath.2007.061098.

Anti-viral T-cell immunity+anti-CNS autoantibody=a model for human acute disseminated encephalomyelitis or multiple sclerosis relapse?

Raymond A Sobel  1
Affiliations
Comment

Anti-viral T-cell immunity+anti-CNS autoantibody=a model for human acute disseminated encephalomyelitis or multiple sclerosis relapse?

Raymond A Sobel. Am J Pathol. 2007 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Representative fields demonstrate the spectrum of lesion pathology in the CNS of a previously neurologically intact 70-year-old man who developed ADEM 1 week following an influenza vaccination and who died 6 weeks later following aspiration pneumonia and sepsis. A: Typical perivascular mononuclear cell inflammatory cuff in cerebellar white matter with relative preservation of surrounding parenchyma. Most of the cells are small lymphocytes, but some are foamy macrophages, suggesting adjacent myelin breakdown and phagocytosis. B: Serial section to A with mostly intact myelin (blue) and axons (black). C: Cerebellar white matter inflammatory/demyelinating focus with prominent perivascular vacuolation (edema). D: Serial section to C demonstrating inflammation, perivascular edema, and demyelination. E: Upper cervical spinal cord lesion with marked neutrophil infiltrates and relative preservation of anterior horn cell somata (arrows). F: Serial section to E highlighting both neutrophil (lower portion of figure) and mononuclear cell infiltration of parenchyma and demyelination. One preserved neuron cell body is seen (arrow). Myelin is relatively preserved in the upper portion of the field. G: Completely demyelinated upper cervical cord lesion with vessel wall breakdown and diffuse fibrin exudation. There are numerous parenchymal neutrophils in the peripheral portions of the field. H: Upper cervical spinal cord lesion with axon retraction bulbs (arrows) indicating transection. A, C, E, hematoxylin and eosin; B, H, Luxol fast blue-Bielschowsky preparation; D, F, G, Klüver-Barrera stain. Original magnifications: A, B, ×160; C–G, ×80; H, ×200.
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References

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