Translating animal research into clinical benefit
- PMID: 17255568
- PMCID: PMC1782020
- DOI: 10.1136/bmj.39104.362951.80
Translating animal research into clinical benefit
Abstract
Poor methodological standards in animal studies mean that positive results rarely translate to the clinical domain
Conflict of interest statement
Comment in
-
Studies in animals should be more like those in humans.BMJ. 2007 Feb 10;334(7588):274. doi: 10.1136/bmj.39115.419236.1F. BMJ. 2007. PMID: 17289696 Free PMC article. No abstract available.
Comment on
-
Comparison of treatment effects between animal experiments and clinical trials: systematic review.BMJ. 2007 Jan 27;334(7586):197. doi: 10.1136/bmj.39048.407928.BE. Epub 2006 Dec 15. BMJ. 2007. PMID: 17175568 Free PMC article.
References
-
- Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock P, et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 2007. doi: 10.1136/bmj.39048.407928.BE - DOI - PMC - PubMed
-
- Hackam DG, Redelmeier DA. Translation of research evidence from animals to humans. JAMA 2006;296:1731-2. - PubMed
-
- Corpet DE, Pierre F. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. Eur J Cancer 2005;41:1911-22. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources