Isolation and structure elucidation of neofusapyrone from a marine-derived Fusarium species, and structural revision of fusapyrone and deoxyfusapyrone

Abstract

Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by extensive ID- and 2D-NMR and MS spectral analyses. Fusapyrone and deoxyfusapyrone were originally reported as a-pyrone derivatives; however, the revised structures indicate that they are gamma-pyrone derivatives. These three compounds exhibited antimicrobial activities.