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. 2006 Nov;59(11):724-8.
doi: 10.1038/ja.2006.97.

RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus

Yukihiro Asami  1 , Hideaki Kakeya, Gen Okada, Masakazu Toi, Hiroyuki Osada
Affiliations

RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus

Yukihiro Asami et al. J Antibiot (Tokyo). 2006 Nov.

Abstract

We found that the strain Aspergillus fumigatus var. fumigatus RK95-113 produced a new angiogenesis inhibitor, RK-95113. Spectroscopic analyses identified the structure of RK-95113 as a new fumagillin-related small molecule. RK-95113 preferentially inhibited the growth of human umbilical vein endothelial cells (HUVECs) rather than that of human normal fibroblasts in cell proliferation assays and blocked endothlial cell migration induced by vascular endothelial growth factor (VEGF).

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