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. 2006 Nov;59(11):729-34.
doi: 10.1038/ja.2006.98.

Structure-activity relationships of xanthocillin derivatives as thrombopoietin receptor agonist

Takahiro Yamaguchi  1 , Yumi Miyake, Atsushi Miyamura, Norihisa Ishiwata, Kuniaki Tatsuta
Affiliations

Structure-activity relationships of xanthocillin derivatives as thrombopoietin receptor agonist

Takahiro Yamaguchi et al. J Antibiot (Tokyo). 2006 Nov.

Abstract

Xanthocillin derivatives, which show thrombopoietin receptor agonist activity, were synthesized through our developed method. Bioassay data suggest the importance of alkene geometry, the presence of substituents at the benzene ring that support hydrophobic character, and the moderate size of the molecule. One of the two isonitrile group of the natural product appears to be dispensable.

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