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. 2006 Dec;26(12):1745-8.

[Preparation of porous polylactic-acid/ bone matrix gelatin composite as scaffold materials for bone-tissue engineering]

[Article in Chinese]
Yu-min Zhang  1 , Bao-xing Li, Ji Li, Hong-qiang Ma, Ya-ping Zhao, Lin Yuan
Affiliations
  • PMID: 17259111

[Preparation of porous polylactic-acid/ bone matrix gelatin composite as scaffold materials for bone-tissue engineering]

[Article in Chinese]
Yu-min Zhang et al. Nan Fang Yi Ke Da Xue Xue Bao. 2006 Dec.

Abstract

Objective: To develop a novel porous poly lactic-acid(PLA)/bone matrix gelatin (BMG) bioactive composite biomaterial with supercritical carbon dioxide (SC-CO2) extraction and determine the optimal proportion of the ingredients by evaluating the physical and chemical characteristics and cellular compatibility of the composites.

Methods: The PLA/BMG composite biomaterials with various PLA/BMG proportions were prepared with SC-CO2 technique and evaluated by macroscopic observation, porosity and mechanical assessment, and scanning electron micrograph (SEM). The optimal proportion of PLA/BMG was determined in conjunction with the results of cellular compatibility evaluation.

Results: BMG proportion in BLA/BMG composite biomaterials prepared with SC-CO2 technique was positively associated with the cellular compatibility and porosity, and inversely with the mechanics of the prepared composite. The results showed BMG content of 30% in PLA/BMG composite was optimal.

Conclusion: The composite with PLA and BMG proportion of 7:3 possesses good physical and chemical characteristics and cellular compatibility, suggesting its potential as the bone implant biomaterial and bone-tissue engineering scaffold.

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