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. 2007 Jan;27(1):72-4.

[Role of dendritic cells in graft rejection after penetrating keratoplasty]

[Article in Chinese]
Lang Bai  1 , Xiao-He Lu, Sen-Tao Dang, Jin Zhou
Affiliations
  • PMID: 17259151

[Role of dendritic cells in graft rejection after penetrating keratoplasty]

[Article in Chinese]
Lang Bai et al. Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jan.

Abstract

Objective: To gain insight into the role of dendritic cells in graft rejection following penetrating keratoplasty by investigating their distribution in rat cornea.

Methods: Orthotopical corneal transplantation was performed and immunohistochemical staining of the whole-mount cornea and the spleen tissue specimen employed to determine the distribution of the dendritic cells in the cornea.

Results: Graft rejection occurred in all rats following the transplantation. No OX-62(+) dendritic cells were found in normal cornea but they were present in the epithelium of the cornea graft with allograft rejection.

Conclusion: OX-62(+) dendritic cells presenting in the rejected cornea may be related to acute graft rejection after penetrating keratoplasty.

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