Review
doi: 10.1038/nri2017.
Humanized mice in translational biomedical research
Affiliations
- PMID: 17259968
- DOI: 10.1038/nri2017
Item in Clipboard
Review
Humanized mice in translational biomedical research
Nat Rev Immunol.
2007 Feb.
Abstract
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
Similar articles
-
Generation of transgenic mice on an NOD/SCID background using the conventional microinjection technique.Biol Reprod. 2011 Apr;84(4):682-8. doi: 10.1095/biolreprod.110.087106. Epub 2010 Dec 8. Biol Reprod. 2011. PMID: 21148106
-
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.Ann N Y Acad Sci. 2007 Apr;1103:90-3. doi: 10.1196/annals.1394.011. Epub 2007 Mar 21. Ann N Y Acad Sci. 2007. PMID: 17376822
-
Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.Ann N Y Acad Sci. 2007 Apr;1103:77-89. doi: 10.1196/annals.1394.002. Epub 2007 Mar 1. Ann N Y Acad Sci. 2007. PMID: 17332083
-
Humanized mice: current states and perspectives.Immunol Lett. 2012 Aug 30;146(1-2):1-7. doi: 10.1016/j.imlet.2012.03.009. Epub 2012 Apr 9. Immunol Lett. 2012. PMID: 22507217 Review.
-
[Mice are not Men and yet… how humanized mice inform us about human infectious diseases].Med Sci (Paris). 2012 Jan;28(1):63-8. doi: 10.1051/medsci/2012281018. Epub 2012 Jan 27. Med Sci (Paris). 2012. PMID: 22289832 Review. French.
Cited by
-
Regulatory considerations for clinical development of cancer vaccines.Hum Vaccin Immunother. 2014;10(11):3409-14. doi: 10.4161/21645515.2014.982999. Hum Vaccin Immunother. 2014. PMID: 25625933 Free PMC article. Review.
-
Humanized Mice for Infectious and Neurodegenerative disorders.Retrovirology. 2021 Jun 5;18(1):13. doi: 10.1186/s12977-021-00557-1. Retrovirology. 2021. PMID: 34090462 Free PMC article. Review.
-
A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.J Biol Chem. 2016 Jun 10;291(24):12724-12731. doi: 10.1074/jbc.M116.725325. Epub 2016 Apr 16. J Biol Chem. 2016. PMID: 27129215 Free PMC article.
-
Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies.NPJ Precis Oncol. 2022 Oct 23;6(1):75. doi: 10.1038/s41698-022-00320-5. NPJ Precis Oncol. 2022. PMID: 36274097 Free PMC article.
-
Detergent-Free Decellularization Preserves the Mechanical and Biological Integrity of Murine Tendon.Tissue Eng Part C Methods. 2022 Dec;28(12):646-655. doi: 10.1089/ten.TEC.2022.0135. Tissue Eng Part C Methods. 2022. PMID: 36326204 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
