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. 2007 Mar;10(3):277-9.
doi: 10.1038/nn1843. Epub 2007 Jan 28.

Direct activation of the ion channel TRPA1 by Ca2+

Sandra Zurborg  1 , Brian Yurgionas, Julia A Jira, Ombretta Caspani, Paul A Heppenstall
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Direct activation of the ion channel TRPA1 by Ca2+

Sandra Zurborg et al. Nat Neurosci. 2007 Mar.

Abstract

TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca(2+)](i) during cooling in heterologous systems.

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