Neonatal seizures: is a novel, mechanism-based treatment finally on the horizon?

Comment

Carl E Stafstrom. Epilepsy Curr. 2006 Jul-Aug.

. 2006 Jul-Aug;6(4):130-2.

doi: 10.1111/j.1535-7511.2006.00121.x.

No abstract available

Comment in

Mechanism-Based Treatment for Neonatal Seizures: Still on the Horizon.
Stafstrom CE. Stafstrom CE. Epilepsy Curr. 2020 Nov-Dec;20(6_suppl):53S-55S. doi: 10.1177/1535759720954253. Epub 2020 Oct 6. Epilepsy Curr. 2020. PMID: 33021401 Free PMC article. No abstract available.

Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus.
Sipilä ST, Huttu K, Soltesz I, Voipio J, Kaila K. Sipilä ST, et al. J Neurosci. 2005 Jun 1;25(22):5280-9. doi: 10.1523/JNEUROSCI.0378-05.2005. J Neurosci. 2005. PMID: 15930375 Free PMC article.
NKCC1 transporter facilitates seizures in the developing brain.
Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. Dzhala VI, et al. Nat Med. 2005 Nov;11(11):1205-13. doi: 10.1038/nm1301. Epub 2005 Oct 9. Nat Med. 2005. PMID: 16227993

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