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. 2007 Mar 1;9(5):931-4.
doi: 10.1021/ol070037p. Epub 2007 Jan 30.

On-demand generation of an efficient catalyst for pyridine formation from unactivated nitriles and alpha,omega-diynes using CoCl2-6H2O, dppe, and Zn

Kouki Kase  1 , Avijit Goswami, Kazuhiko Ohtaki, Emi Tanabe, Naoko Saino, Sentaro Okamoto
Affiliations

On-demand generation of an efficient catalyst for pyridine formation from unactivated nitriles and alpha,omega-diynes using CoCl2-6H2O, dppe, and Zn

Kouki Kase et al. Org Lett. .

Abstract

[reaction: see text] A highly practical, general method for catalytic formation of substituted pyridines from a variety of unactivated nitriles and alpha,omega-diynes is given. The reactions which were catalyzed by 5 mol % of dppe/CoCl2-6H2O in the presence of Zn powder (10 mol %) could proceed at rt to approximately 50 degrees C with high functional compatibility and regioselectivity.

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