Review
doi: 10.1016/j.bbamem.2006.12.006.
Epub 2006 Dec 14.
G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
Affiliations
- PMID: 17261268
- DOI: 10.1016/j.bbamem.2006.12.006
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Review
G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
Biochim Biophys Acta.
2007 Apr.
Free article
Abstract
Long-term potentiation (LTP) and long-term depression (LTD) are the major forms of functional synaptic plasticity observed at CA1 synapses of the hippocampus. The balance between LTP and LTD or "metaplasticity" is controlled by G-protein coupled receptors (GPCRs) whose signal pathways target the N-methyl-D-asparate (NMDA) subtype of excitatory glutamate receptor. We discuss the protein kinase signal cascades stimulated by Galphaq and Galphas coupled GPCRs and describe how control of NMDAR activity shifts the threshold for the induction of LTP.
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