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Case Reports
. 2007 Jan;85(1):70-2.
doi: 10.1532/IJH9706129.

Treatment of McLeod phenotype chronic granulomatous disease with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation

Nobuhiro Suzuki  1 , Naoki Hatakeyama, Masaki Yamamoto, Nobuo Mizue, Yuki Kuroiwa, Minami Yoda, Junko Takahashi, Yoshihiko Tani, Hiroyuki Tsutsumi
Affiliations
Case Reports

Treatment of McLeod phenotype chronic granulomatous disease with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation

Nobuhiro Suzuki et al. Int J Hematol. 2007 Jan.

Abstract

Patients with chronic granulomatous disease (CGD) complicated by antimycotics-refractory invasive aspergillosis have an extremely poor prognosis if they cannot undergo allogeneic hematopoietic stem cell transplantation from a suitable related donor while in good clinical condition. We successfully treated a 20-year-old man with very rare McLeod phenotype CGD with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation. We postulate that reduced-intensity conditioning-allogeneic hematopoietic stem cell transplantation is a promising therapeutic strategy for patients with CGD even if only unrelated-donor umbilical cord blood is available.

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