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Review
. 2007 Feb;38(2 Suppl):759-62.
doi: 10.1161/01.STR.0000247868.97078.10.

Brain injury after intracerebral hemorrhage: the role of thrombin and iron

Ya Hua  1 , Richard F Keep, Julian T Hoff, Guohua Xi
Affiliations
Review

Brain injury after intracerebral hemorrhage: the role of thrombin and iron

Ya Hua et al. Stroke. 2007 Feb.

Abstract

Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury.

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