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. 2007 Mar;70(3):361-6.
doi: 10.1021/np060506g. Epub 2007 Jan 31.

Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest

Shugeng Cao  1 , Andrew Norris, James S Miller, Fidy Ratovoson, Jeremi Razafitsalama, Rabodo Andriantsiferana, Vincent E Rasamison, Karen TenDyke, Ted Suh, David G I Kingston
Affiliations

Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest

Shugeng Cao et al. J Nat Prod. 2007 Mar.

Abstract

Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Albizia gummifera led to the isolation of three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C (1-3). The structures of these new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1-3 showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.

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Figures

Figure 1
Figure 1
Key HMBC (arrows) and ROESY (dashed) correlations for compound 1
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