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. 2007 Jan 30:5:12.
doi: 10.1186/1477-7819-5-12.

Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region

Manoj Pandey  1 , Latha P Rao, Shaima R Das, Anitha Mathews, Elizabeth M Chacko, B R Naik
Affiliations

Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region

Manoj Pandey et al. World J Surg Oncol. .

Abstract

Background: Mandibular resections are routinely carried out for achieving a R0 resection for oral cancers. However, the need of mandibular resection to achieve this has always been questioned. The present study was carried out to define the pattern of mandibular involvement in carcinoma of the mandibular region.

Patients and methods: A total of 25 consecutive patients who had undergone mandibular resection and were found to have mandibular invasion were studied in a prospective open fashion. After decalcification the specimens were serially sectioned at 1 cm interval to identify invasion of mandibular bone. Type of invasion, route of spread and host cell reactions were also recorded.

Results: The mandibular involvement was infiltrative in 14(56%) and erosive in 11(44%). It was cortical in 5(20%), marrow involvement was seen in 15(60%) while 5(20%) had spread through the inferior alveolar canal. Of the 25, 24(96%) lesions were located with in 1 cm of the mandible.

Conclusion: The possibility of mandibular involvement is higher in patients where tumours are located with in 1 cm of the mandible. Involvement of mandible through the canal of inferior alveolar nerve in the present study was relatively high (20%). Therefore it is recommended that before a decision is taken to preserve the mandible it should be thoroughly screened for possible involvement.

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Figures

Figure 1
Figure 1
Tumour invasion in mandible in a broad front (E) characteristic of erosive pattern with no bony remnants within the tumour mass tumour cells are separated from the normal bone by a well demarcated fibrous zone (F).
Figure 2
Figure 2
Tumour invasion in the mandible as irregular cords and islands (I) characteristic of infiltrative pattern, partially lysed bone spicules (B) are present within the tumour mass with no clear cut demarcating tissue between tumour and bone.
Figure 3
Figure 3
Tumour invasion (T) into the perineural space of the inferior alveolar nerve bundles.
Figure 4
Figure 4
Tumour invasion (T) into the mandible involving the superior portion of the inferior alveolar canal with no invasion of nerve bundles (N).
Figure 5
Figure 5
Diffuse irregular tumour infiltrating bone, fibrous marrow (FM) and bony remnants (B).
Figure 6
Figure 6
Fatty marrow in post radiotherapy patient.
See this image and copyright information in PMC

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References

    1. Soderholm AL, Lindquist C, Hietanen J, Lukinmaa PL. Bone scanning for evaluating mandibular bone extension of oral squamous cell carcinoma. J Oral Maxillofac Surg. 1990;48:252–257. - PubMed
    1. Carter RL, Foster CS, Dinsdale EA, Pittman MR. Perineural spread by squamous carcinomas of the head and neck a morphological study using anti axonal and anti myelin monoclonal antibodies. J Clin Pathol. 1983;36:269–275. - PMC - PubMed
    1. Marchetta FC, Sako K, Murphy JB. The periosteum of the mandible and intra oral carcinoma. Am J Surg. 1964;108:505–507. doi: 10.1016/0002-9610(64)90144-8. - DOI - PubMed
    1. Bahadur S. Mandibular involvement in oral cancer. J Laryngol Otol. 1990;104:968–971. - PubMed
    1. Barttelbort SW, Bahn SL, Ariyan S. Rim mandibulectomy for cancer of the oral cavity. Am J Surg. 1987;154:43–48. doi: 10.1016/0002-9610(89)90017-2. - DOI - PubMed

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