Review
doi: 10.1039/b603842p.
Epub 2006 Nov 27.
Chemical double-mutant cycles: dissecting non-covalent interactions
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- PMID: 17264921
- DOI: 10.1039/b603842p
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Review
Chemical double-mutant cycles: dissecting non-covalent interactions
Chem Soc Rev.
2007 Feb.
Abstract
Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.
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