Ionic channels: modulation by G proteins and by phosphorylation
- PMID: 1726583
- DOI: 10.1016/0959-4388(91)90007-t
Ionic channels: modulation by G proteins and by phosphorylation
Abstract
The gating of ion channels may be modulated by G proteins or by phosphorylation. Direct coupling between G proteins and ion channels has been shown in excised patches of membrane. Steps must now be taken to study the protein domains of G proteins and ion channels involved in the mutual interaction. The concept of channel modulation by protein kinases has recently been extended to include additional types of ion channel.
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