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. 2007 Mar 15;17(6):1722-5.
doi: 10.1016/j.bmcl.2006.12.076. Epub 2006 Dec 24.

Oxazolidinones as novel human CCR8 antagonists

Jian Jin  1 , Yonghui Wang, Feng Wang, Jeffery K Kerns, Victoria M Vinader, Ashley P Hancock, Matthew J Lindon, Graeme I Stevenson, Dwight M Morrow, Parvathi Rao, Cuc Nguyen, Victoria J Barrett, Chris Browning, Guido Hartmann, David P Andrew, Henry M Sarau, James J Foley, Anthony J Jurewicz, James A Fornwald, Andy J Harker, Michael L Moore, Ralph A Rivero, Kristen E Belmonte, Helen E Connor
Affiliations

Oxazolidinones as novel human CCR8 antagonists

Jian Jin et al. Bioorg Med Chem Lett. .

Abstract

High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.

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