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Review
. 2007 Jan;83(975):32-9.
doi: 10.1136/pgmj.2006.044826.

Management of patients with HBeAg-negative chronic hepatitis B

Nripen Saikia  1 , Rupjyoti Talukdar, Subhasish Mazumder, Sudeep Khanna, Rakesh Tandon
Affiliations
Review

Management of patients with HBeAg-negative chronic hepatitis B

Nripen Saikia et al. Postgrad Med J. 2007 Jan.

Abstract

Chronic hepatitis B (CHB) is one of the leading causes of morbidity and mortality worldwide. Although various drugs are available for the treatment of CHB, emergence of the hepatitis B e antigen (HBeAg)-negative mutant variant, specifically in Asia, the Middle East and southern Europe, is creating a new challenge as this variant is less responsive to available treatments. HBeAg-negative CHB rapidly progresses to cirrhosis and its related complications. This review discusses the available literature on the approved and under-trial treatment options and their respective efficacies for HBeAg-negative CHB.

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Conflict of interest statement

Competing interests: None declared.

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