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. 2007 Mar 1;17(5):1455-65.
doi: 10.1016/j.bmcl.2006.11.056. Epub 2006 Nov 21.

Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

Ke Wang  1 , Jinfeng Li, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan
Affiliations

Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

Ke Wang et al. Bioorg Med Chem Lett. .

Abstract

Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure-activity relationship (SAR) of Nec-5 series in inhibiting necroptosis.

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