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. 2007 Feb 1;53(3):315-7.
doi: 10.1016/j.neuron.2007.01.013.

Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene

Howard J Federoff  1 , Timothy R Mhyre
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Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene

Howard J Federoff et al. Neuron. .
Free article

Abstract

The prionoses are fatal neurodegenerative diseases caused by a pathogenic protein, PrP scrapie, that derives from misfolding of a normal form, PrP(c). These diseases progress through stages. A new study by Mallucci et al. in this issue of Neuron shows that prion disease may be reversed in mice by selective removal of the gene in neurons after early physiological, cognitive, and pathological features have developed.

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