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Review
. 2007 Feb 6;104(6):1743-4.
doi: 10.1073/pnas.0610874104. Epub 2007 Feb 1.

Malarial fever: hemozoin is involved but Toll-free

Ralf R Schumann  1
Affiliations
Review

Malarial fever: hemozoin is involved but Toll-free

Ralf R Schumann. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Potential mechanism of malaria-induced fever. Parroche et al. (4) show that hemozoin contains plasmodial DNA and that it “presents” or internalizes DNA. Plasmodial DNA then intracellularly interacts with TLR9, initiating signal transduction leading to the release of proinflammatory cytokines via NF-κB activation. These cytokines induce COX-2-up-regulating prostaglandins, which subsequently leads to the induction of fever.
See this image and copyright information in PMC

Comment on

References

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