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. 2007;8(1):201.
doi: 10.1186/gb-2007-8-1-201.

Analysis of genetic systems using experimental evolution and whole-genome sequencing

Matthew Hegreness  1 , Roy Kishony
Affiliations

Analysis of genetic systems using experimental evolution and whole-genome sequencing

Matthew Hegreness et al. Genome Biol. 2007.

Abstract

The application of whole-genome sequencing to the study of microbial evolution promises to reveal the complex functional networks of mutations that underlie adaptation. A recent study of parallel evolution in populations of Escherichia coli shows how adaptation involves both functional changes to specific proteins as well as global changes in regulation.

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