Glucocorticoid receptor-binding site in the human immunodeficiency virus long terminal repeat
- PMID: 1727502
- PMCID: PMC238321
- DOI: 10.1128/JVI.66.1.586-590.1992
Glucocorticoid receptor-binding site in the human immunodeficiency virus long terminal repeat
Abstract
Previous reports (P. D. Katsanakis, C. E. Sekaris, and D. A. Spandidos, Anticancer Res. 11:381-383, 1991; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; R. Miksicek, A. Heber, W. Schmid, U. Danesch, G. Posseckert, M. Beato, and G. Schutz, Cell 46:283-290, 1986) have suggested the existence of a glucocorticoid response element in the long terminal repeat of human immunodeficiency virus (HIV) type 1. This study demonstrated a sequence-specific interaction of the glucocorticoid receptor DNA-binding domain with the previously predicted HIV glucocorticoid response element. This interaction may be relevant to the steroid responsiveness of HIV (P. A. Furth, H. Westphal, and L. Hennighausen, AIDS Res. Hum. Retroviruses 6:553-560, 1990; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; J. Laurence, H. Cooke, and S. K. Sikder, Blood 75:696-703, 1990; D. A. Spandidos, V. Zoounpovilis, A. Kotsinas, C. Tsiripotis, and C. E. Sekeris, Anticancer Res. 10:1241-1246, 1990).
Similar articles
-
Role of glucocorticoid receptor binding sites in the human immunodeficiency virus type 1 long terminal repeat in steroid-mediated suppression of HIV gene expression.Virology. 1995 Dec 20;214(2):512-21. doi: 10.1006/viro.1995.0062. Virology. 1995. PMID: 8553553
-
Glucocorticoids suppress human immunodeficiency virus type-1 long terminal repeat activity in a cell type-specific, glucocorticoid receptor-mediated fashion: direct protective effects at variance with clinical phenomenology.J Steroid Biochem Mol Biol. 2000 Dec 31;75(4-5):283-90. doi: 10.1016/s0960-0760(00)00187-4. J Steroid Biochem Mol Biol. 2000. PMID: 11282284
-
Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.Proc Natl Acad Sci U S A. 1984 May;81(10):3029-33. doi: 10.1073/pnas.81.10.3029. Proc Natl Acad Sci U S A. 1984. PMID: 6328488 Free PMC article.
-
Protein-protein interactions facilitate DNA binding by the glucocorticoid receptor DNA-binding domain.J Biol Chem. 1990 Aug 15;265(23):14030-5. J Biol Chem. 1990. PMID: 1974254
-
Regulatory elements in the human immunodeficiency virus type 1 long terminal repeat LTR (HIV-1) responsive to steroid hormone stimulation.AIDS Res Hum Retroviruses. 1992 Dec;8(12):1977-80. doi: 10.1089/aid.1992.8.1977. AIDS Res Hum Retroviruses. 1992. PMID: 1493048
Cited by
-
A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter.Nucleic Acids Res. 2000 Feb 1;28(3):663-8. doi: 10.1093/nar/28.3.663. Nucleic Acids Res. 2000. PMID: 10637316 Free PMC article. Review.
-
The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.Med Res Rev. 2006 Sep;26(5):595-625. doi: 10.1002/med.20081. Med Res Rev. 2006. PMID: 16838299 Free PMC article. Review.
-
Glucocorticoids and central nervous system inflammation.J Neurovirol. 2002 Dec;8(6):513-28. doi: 10.1080/13550280290100914. J Neurovirol. 2002. PMID: 12476346 Review.
-
T-Cell Signaling in HIV-1 Infection.Open Virol J. 2013 Jul 26;7:57-71. doi: 10.2174/1874357920130621001. eCollection 2013. Open Virol J. 2013. PMID: 23986795 Free PMC article.
-
Transcription factor access to chromatin.Nucleic Acids Res. 1997 Sep 15;25(18):3559-63. doi: 10.1093/nar/25.18.3559. Nucleic Acids Res. 1997. PMID: 9278473 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
