Review
doi: 10.1016/j.smim.2006.12.004.
Epub 2007 Feb 1.
TLR signaling
Affiliations
- PMID: 17275323
- DOI: 10.1016/j.smim.2006.12.004
Item in Clipboard
Review
TLR signaling
Semin Immunol.
2007 Feb.
Abstract
The TLR family senses the molecular signatures of microbial pathogens, and plays a fundamental role in innate immune responses. TLRs signal via a common pathway that leads to the expression of diverse inflammatory genes. In addition, each TLR elicits specific cellular responses to pathogens owing to differential usage of intracellular adapter proteins. Recent studies have revealed the importance of the subcellular localization of TLRs in pathogen recognition and signaling. TLR signaling pathways is negatively regulated by a number of cellular proteins to attenuate inflammation. Here, we describe recent advances in our understanding of the regulation of TLR-mediated signaling.
Similar articles
-
Toll-like receptors in innate immunity.Int Immunol. 2005 Jan;17(1):1-14. doi: 10.1093/intimm/dxh186. Int Immunol. 2005. PMID: 15585605 Review.
-
Toll-like receptors and innate immunity.Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5. doi: 10.1016/j.bbrc.2009.08.062. Epub 2009 Aug 15. Biochem Biophys Res Commun. 2009. PMID: 19686699 Review.
-
Signaling to NF-kappaB by Toll-like receptors.Trends Mol Med. 2007 Nov;13(11):460-9. doi: 10.1016/j.molmed.2007.09.002. Epub 2007 Oct 29. Trends Mol Med. 2007. PMID: 18029230 Review.
-
Direct and indirect role of Toll-like receptors in T cell mediated immunity.Cell Mol Immunol. 2004 Aug;1(4):239-46. Cell Mol Immunol. 2004. PMID: 16225766 Review.
-
Glucocorticoids and the innate immune system: crosstalk with the toll-like receptor signaling network.Mol Cell Endocrinol. 2007 Sep 15;275(1-2):30-42. doi: 10.1016/j.mce.2007.04.014. Epub 2007 May 13. Mol Cell Endocrinol. 2007. PMID: 17576036 Review.
Cited by
-
Neurosteroid allopregnanolone (3α,5α-THP) inhibits inflammatory signals induced by activated MyD88-dependent toll-like receptors.Transl Psychiatry. 2021 Feb 26;11(1):145. doi: 10.1038/s41398-021-01266-1. Transl Psychiatry. 2021. PMID: 33637705 Free PMC article.
-
The Anti-Sepsis Effect of Isocorydine Screened from Guizhou Ethnic Medicine is Closely Related to Upregulation of Vitamin D Receptor Expression and Inhibition of NFκB p65 Translocation into the Nucleus.J Inflamm Res. 2022 Oct 3;15:5649-5664. doi: 10.2147/JIR.S365191. eCollection 2022. J Inflamm Res. 2022. PMID: 36211222 Free PMC article.
-
The expression of Toll-like receptors in murine Müller cells, the glial cells in retina.Neurol Sci. 2013 Aug;34(8):1339-46. doi: 10.1007/s10072-012-1236-1. Epub 2012 Dec 4. Neurol Sci. 2013. PMID: 23207548 Free PMC article.
-
Beyond pattern recognition: five immune checkpoints for scaling the microbial threat.Nat Rev Immunol. 2012 Feb 24;12(3):215-25. doi: 10.1038/nri3167. Nat Rev Immunol. 2012. PMID: 22362354
-
An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling.Traffic. 2022 Dec;23(12):558-567. doi: 10.1111/tra.12870. Epub 2022 Oct 24. Traffic. 2022. PMID: 36224049 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
