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. 1992 Jan;130(1):544-6.
doi: 10.1210/endo.130.1.1727722.

Detection and identification of endothelin-1 immunoreactivity in rat and porcine thyroid follicular cells

I Colin  1 , A Berbinschi, J F Denef, J M Ketelslegers
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Detection and identification of endothelin-1 immunoreactivity in rat and porcine thyroid follicular cells

I Colin et al. Endocrinology. 1992 Jan.

Abstract

Endothelin-1 immunoreactivity (irET-1) was observed in rat and porcine thyroid glands. Using a radioimmunoassay for endothelin-1, the mean concentration in extracts of rat and porcine thyroid glands were 0.75 pg/mg +/- 0.03 (n = 4) and 1.5 pg/mg +/- 0.2 (n = 8) (mean +/- SE) respectively. Gel-filtration and reverse-phase HPLC showed that ir ET-1 eluted in a position identical to synthetic endothelin-1. In addition, immunohistochemical study showed that irET-1 is located within epithelial follicular cells. No immunostaining was seen in parafollicular C-cells nor in parathyroid.

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