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. 2007 Sep;93(9):1046-50.
doi: 10.1136/hrt.2006.102657. Epub 2007 Feb 3.

Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure

Yoav Michowitz  1 , Emil Goldstein, Dov Wexler, David Sheps, Gad Keren, Jacob George
Affiliations

Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure

Yoav Michowitz et al. Heart. 2007 Sep.

Abstract

Background: Circulating endothelial progenitor cells (EPCs) are increased in conditions associated with ischaemia and can potentially support angiogenesis and vasculogenesis. EPC levels were also shown to predict outcome in patients with atherosclerotic vascular disease. We tested the hypothesis that circulating EPC can predict outcome in patients with congestive heart failure (CHF).

Methods: EPC-colony-forming units were measured in the peripheral blood of 107 consecutive patients with CHF with New York Heart Association (NYHA) functional class II-IV. Serum levels of vascular endothelial growth factor (VEGF), N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and high-sensitivity C-reactive protein (hsCRP) were also measured. End points were defined as CHF-related hospital admissions and all-cause mortality.

Results: Age (p = 0.01), diabetes mellitus (p = 0.002) and EPC levels (p = 0.02) were found to be independent predictors of all-cause mortality. EPC levels did not predict CHF-related hospitalisations. EPC levels correlated positively with NYHA (p = 0.05, r = 0.19), but did not correlate with VEGF, NT-pro-BNP or hsCRP. EPC levels did not differ by the aetiology of CHF.

Conclusions: EPC levels are independent predictors of all-cause mortality among patients with CHF.

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Conflict of interest statement

Competing interests: None declared.

References

    1. McMurray J J, Pfeffer M A. The year in heart failure. J Am Coll Cardiol 2004442398–2405. - PubMed
    1. Young J B. Management of chronic heart failure: what do recent clinical trials teach us? Rev Cardiovasc Med 20045(Suppl 1)S3–S9. - PubMed
    1. Fischer D, Rossa S, Landmesser U.et al Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death. Eur Heart J 20052665–69. - PubMed
    1. Kosiborod M, Smith G L, Radford M J.et al The prognostic importance of anemia in patients with heart failure. Am J Med 2003114112–119. - PubMed
    1. Tsutamoto T, Wada A, Maeda K.et al Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation 199796509–516. - PubMed

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