Review
doi: 10.1039/b610344h.
Epub 2006 Sep 25.
Chemistry and biology of resorcylic acid lactones
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- PMID: 17279252
- DOI: 10.1039/b610344h
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Review
Chemistry and biology of resorcylic acid lactones
Chem Commun (Camb).
.
Abstract
While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.
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