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. 1975 Aug;62(8):385-9.
doi: 10.1007/BF00625346.

Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells

M S Brown, J L Goldstein

Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells

M S Brown et al. Naturwissenschaften. 1975 Aug.

Abstract

Biochemical analysis of cultured fibroblasts obtained from human subjects with the autosomal dominant disorder familial hypercholesterolemia has led to the identification of a hitherto unrecognized cell-surface receptor for serum lipoproteins. This receptor plays a critical role in the physiologic regulation of cholesterol metabolism in human cells, and its absence leads to elevation of serum-cholesterol levels and severe atheroslerosis.

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