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Review
. 2007 Jan;19(1 Suppl):89-119.
doi: 10.1111/j.1365-2982.2006.00876.x.

Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity

L Bueno  1 , F de Ponti, M Fried, G A Kullak-Ublick, M A Kwiatek, D Pohl, E M M Quigley, J Tack, N J Talley
Affiliations
Review

Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity

L Bueno et al. Neurogastroenterol Motil. 2007 Jan.

Abstract

Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

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